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Kirtawade, Rupali
- Simultaneous UV-Spectrophotometric Method for Estimation of Atenolol and Losartan Potassium in Tablet Dosage Form
Abstract Views :179 |
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Authors
Rupali Kirtawade
1,
Pallavi Salve
1,
Chhotaram Seervi
1,
Kiran Patil
1,
Anita Kulkarni
1,
Pandurang Dhabale
1
Affiliations
1 Govt. College of Pharmacy, Karad-415124, (Satara), Maharashtra, IN
1 Govt. College of Pharmacy, Karad-415124, (Satara), Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 4 (2010), Pagination: 1050-1053Abstract
Two simple, accurate, precise, reproducible and economical procedures for simultaneous estimation of Atenolol (AT) and Losartan Potassium (LP) in tablet dosage form have been developed. First method based on solving of simultaneous equation using 226 nm (λmax of AT) and 208 nm (λmax of LP) as two analytical wavelengths for both drugs in Methanol solvent. Second method based on an equation of area calculation of curve at two wavelength region (231 to 221 nm and 213 to 203 nm). Linearity was observed in the concentration range of 6-36 μg/ml for AT and 2-16 μg/ml for LP. The results of analysis have been validated statistically and by recovery study.Keywords
Atenolol, Losartan Potassium, λmax, Simultaneous Estimation Method, Area Under Curve (AUC).- Simultaneous UV Spectrophotometric Method for Estimation of Amlodipine Besylate and Lisinopril in Tablet Dosage Form
Abstract Views :159 |
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Authors
Affiliations
1 Govt. College of Pharmacy, Karad-415124 (Satara), Maharashtra, IN
1 Govt. College of Pharmacy, Karad-415124 (Satara), Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 201-204Abstract
Two simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of Amlodipine Besylate and Lisinopril in tablet dosage form have been developed. First method employs formation and solving of simultaneous equation using 239 nm and 207 nm as two analytical wavelengths for both drugs in Triple distilled water. The second method is Q value analysis based on measurement of absorptivity at 212.5 nm (as an iso-absorptive point) and 239 nm. Amlodipine Besylate and Lisinopril at their respective λmax 239 nm and 207 nm and at isoabsorptive point 212.5 nm shows linearity in a concentration range of 5-30 μg/mL. Recovery studies range from 101.49% for Amlodipine Besylate and 99.27% for Lisinopril in case of simultaneous equation method and 100.76% for Amlodipine Besylate and 99.73% for Lisinopril in case of Q-analysis method confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific.Keywords
Amlodipine Besylate, Lisinopril λmax, Simultaneous Equation Method, Q Analysis.- Simple Validated Spectroscopic Method for Estimation of Amlodipine Besylate from Tablet Formulation
Abstract Views :151 |
PDF Views:0
Authors
Affiliations
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S., IN
1 Government College of Pharmacy, Karad-415124, Dist Satara, M.S., IN